Hydroxychloroquine Tablets Photo: Time

Malaria drug Trump publicises for Coronavirus fails another test ─Study

* Finds ‘hydroxycholoquine doesn’t help COVID-19 patients, poses higher risk of death’

Isola Moses | ConsumerConnect

In the course of finding a potent cure for, and fighting against the devastating Coronavirus (COVID-19) pandemic currently bleeding the American economy, the malaria treatment which United States President Donald Trump repeatedly championed as a “game changer” again, has failed to show a benefit in patients hospitalised with COVID-19, a study released Thursday, May 7 has revealed.

Hydroxychloroquine Tablets, USP are used to prevent or treat malaria caused by mosquito bites.

The United States Centre for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world.

While the study published in the ‘New England Journal of Medicine’ had certain limitations, doctors informed that the use of hydroxycholoquine neither lessened the need for patients requiring breathing assistance nor the risk of death.

“We didn’t see any association between getting this medicine and the chance of dying or being intubated,” Dr. Neil Schluger, lead researcher, told Reuters in a telephone interview.

“The patients who got the drug didn’t seem to do any better,” Dr. Schluger stated.

The study indicates that among patients given hydroxychloroquine, 32.3% ended up needing a ventilator or dying, compared with 14.9% of patients who were not given the drug.

But doctors were more likely to give hydroxychloroquine to sicker patients, so researchers at New York-Presbyterian Hospital and Columbia University Irving Medical Center adjusted the rates to account for that.

They concluded that the drug may not have hurt patients, but it clearly did not help.

Decades old hydroxychloroquine, which is also used to treat lupus and rheumatoid arthritis, also showed no benefit when combined with the antibiotic azithromycin, Schluger’s team reported. Azithromycin alone also showed no benefit.

In April 2020, doctors at the U.S. Department of Veterans Affairs reported that hydroxychloroquine did not help COVID-19 patients and might pose a higher risk of death.

That analysis of medical records showed a death rate of 28% when the drug was given in addition to standard treatments, compared to 11% with standard care alone. In the latest study, 811 patients got hydroxychloroquine and 565 did not.

Because they were not randomly assigned to receive hydroxychloroquine or a placebo, “the study should not be taken to rule out either benefit or harm” for the drug, researchers said.

Randomised trials, the gold standard for tests of new therapies, should continue, they added.

But for now, “the guidance in our hospital has changed so we don’t recommend giving hydroxychloroquine to hospitalised patients,” said Dr. Schluger, Chief of the Division of Pulmonary, Allergy and Critical Care Medicine at Irving.

Smaller studies, including one done in China, had suggested hydroxychloroquine might be useful, “but these were tiny studies and not of good quality. People seized on them because patients were dying,” he said.

There are currently no approved treatments for COVID-19, although Gilead Sciences Inc’s experimental antiviral drug remdesivir recently received emergency use authorisation from U.S. regulators.

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